role of pi3k subunit p85 in regulation of actin organization and cell migration
| PAG Title | role of pi3k subunit p85 in regulation of actin organization and cell migration |
| PAG ID | WAG001021 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Migration of cells is involved in essential functions such as development, invasiveness of cancer cells, leukocyte movement toward chemotactic sigls, and fibroblast response to injury. Cells can migrate in a specific direction in response to extracellular sigls through pathways that trigger changes in the cytoskeleton, particularly actin filaments, increasing lamellipodia and filopodia formation and decreasing focal adhesions. Factors like PDGF activate PI3 kise and multiple pathways downstream to stimulate cell migration. One pathway regulating migration through the p85 regulatory subunit of PI3 kise does not require PI3-kise activity. In this pathway, p85 of PI3-kise activates cdc42, which activates N-Wasp (Wiskott-Aldrich Syndrome Protein) to regulate ARP-2/3. ARP-2/3 is a complex of proteins localized at the leading edge of moving cells that nucleates the formation of new actin fibers and interacts with Wasp to stimulate migration. The cdc42 pathway also regulates p21-activate kise 1 (PAK1). Another pathway by which PI3 kise regulates migration is through the small GTPase Rac. PAK1 is a downstream target of Rac as well as cdc42. Downstream of Rac and PAK1, Myosin light chain kise (MLCK) phosphorylates myosin light chain to increase cell migration. The regulation of the localization and activity of sigling factors creates coordited pathways linking extracellular sigls and cellular migration. |
| Species | Homo sapiens |
| nCoCo Score | 1,739 |
| Base PAG ID | WAG001021 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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